Tubersol lot number and expiration date 2023

Lot Number Expiration Date Analytical: 1123241782 Verification Batch Name CO Top Loading: 1123253484 Volume: Standard(s) below added to the volumetric flask and QS with the solvent/matrix listed above. Expiration Inventory Amount ... Created Date: 9/21/2023 4:50:35 PM ...

aplisol lot number and expiration date is accessible in our book gathering an online access to it is set as public so you can get it promptly. As established, exploration as expertly as knowledge just about instruction, enjoyment, as adeptly as contract can be gotten by just checking out a book Aplisol Lot Number And Expiration DateThis means you may be able to use your test past the date listed on the package. To find out if your test has FDA-authorized extended dating, follow these simple steps: Find your test's name, manufacturer, expiration date and lot number. The lot number is typically located above the expiration date. Visit the FDA website, scroll down to the ...When an expiration date of a drug is required, e.g., expiration dating of drug products required by § 211.137 of this chapter, it shall appear on the immediate container and also the outer package, if any, unless it is easily legible through such outer package. ... The lot number on the label of a drug should be capable of yielding the ...The endocrine system is a collection of glands that controls many of the body’s essential functions. When they work properly, they keep the human body operating as expected. When they malfunction, one result can be central precocious puberty (CPP). CPP is puberty that occurs much earlier than what’s considered normal.Although taking expired ibuprofen is not recommended by the manufacturer, the actual shelf-life is likely to be longer than that indicated by the expiry date, with FDA testing showing many drugs are active for years beyond their expiry date, although specific data on ibuprofen is not available. Within reason, an ibuprofen tablet that is a few months past its expiry date is probably safe to take.

This is also called the six-digit code. To a large extent, this date format is one of the most common codes used for beer products, and the six digits appear as MMDDYY. As such, you must read the code as the month, day, and last two digits of the year in a successive manner. For instance, "101320" represents an expiry date of October 13, 2020.1 Lot Number - Each case of vials has an 8 character (seven digits, one alpha) lot number that can be found on the Product Description label. This number represents the production lot and associated analysis. 2 Lot Number - Each case of vials has a 12 digit number and bar code label that can be found in the lower left hand corner of the top flap of the vial carton.Also called a far month contract, a back month contract is a futures contract that has an expiration date that is the farthest beyond the next approaching… Also called a far month ...For example: a test with lot number 201843AR or 201843C, would have the same extended expiration date as lot number 201843 indicated on the table. ... 160521 2022-03 -15 2023-01-15 .Table 1: Lot Numbers and Expiration Dates for SNS-held JYNNEOS vaccine. NDC # Lot Number(s) Expiration; 50632-001-01 (vial) 50632-001-02 (20 vials/package) FDP00002 FDP00003 FDP00004 FDP00005. Aug …For products with a limited life span, the lot number and expiration date are very much related. When it happens, you need to track both, expiration date and lot number. An expiration date is a number calculated as the sum of the production date and the average product age duration. For example, let us suppose that today, September 3, 2021, you ...In addition, it is essential that the health professional record the testing history in the permanent medical record of each patient. This permanent office record should contain the name of the product, date given, dose, manufacturer, and lot number, as well as the test result in millimeters of induration (including 0 mm, if appropriate).

Aplisol (tuberculin PPD, diluted) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The solution is stabilized ...Remember, you'll need to properly store both nonperishable and perishable foods if you want them to last this long. Fresh fish: 1 to 2 days. Boneless chicken breast: 1 to 2 days. Sliced deli ...We've got awesome news from Southwest Airlines. As of July 28, 2022, flight credits issued by the carrier no longer have an expiration date. We may be compensated when you click on...aplisol-lot-number-and-expiration-date 1/7 Downloaded from uniport.edu.ng on January 6, 2024 by guest ... brand name of PPD solution (eg, Tubersol or Aplisol), lot number, and expiration date of PPD solution in ... Oct 2023 · aplisol lot number and expiration date is available in our book collection an online access to it

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health authority tuberculin skin test ottawa public health tubersol lot number and expiration date 2023 what you need tb test ppd lot number and ... tb test ppd lot number and expiration date 2023 statcare Sep 01 2022ambulatory EHRs can capture NDC, lot number, and expiration date data by scanning the 2D barcode on the vaccine vial or syringe; can verify that the ordered vaccine is consistent with the vaccine being prepared to be administered; and cancheck the expiration date to ensure that the vaccine is still active. ...[11] What is the Listing Expiration Date? - This is the date when the listing record will expire if not updated or certified by the product labeler. [12] What is the NDC Exclude Flag?Lot Number Test with this printed expiration date Now have this extended expiration date . BA6335, BA6336, BA6349, BA6560, BB6177, BB6241, ... July 2022 February 2023 BB6463, BB6513, BC6527 August ...The following table lists the original dates and, if applicable, extension expiration dates for the following COVID-19 therapeutic products: bamlanivimab, bebtelovimab, etesevimab, Evusheld, Lagevrio (molnupiravir), REGEN-COV, and sotrovimab. Paxlovid (nirmatrelvir co-packaged with ritonavir) expiry data is available from the manufacturer's ...

A vial of TUBERSOL which has been entered and in use for 30 days should be discarded. (23) Do not use after expiration date. REFERENCES. 5 Landi S, et al. Disparity of potency between stabilized and nonstabilized dilute tuberculin solutions. Am Rev Respir Dis 1971;104:385-393. 7 Menzies D. Interpretation of repeated tuberculin tests.Inventory Lot Control. It's important to be have a system that allows for visibility of inventory expiration dates. Lot control functionality associates a code with each replenishment (receipt of inventory) from any supplier. This allows you to easily aggregate goods by their expiration date which is essential for the management of large ...Although the lot numbers are similar, the expiration date of the components within the kit may be different and may impact if the kit is extended. ... After the end of the PHE in May 2023, mandatory coverage for over-the-counter and laboratory-based COVID-19 tests ended. Coverage will vary depending on the health insurance plan.15-month to 18-month self-life extension granted by the FDA September 6, 2023. Lot Number. Tests with this printed expiration date (Year-month-day) Now have this extended expiration date (Year ...12-month to 15-month self-life extension granted by the FDA June 16, 2023 Lot number. Tests with this printed expiration date Now have this extended expiration date. 22S0142 - 22S0166BD Veritor System for Rapid Detection of SARS-CoV-2 & Flu A+B, 30 Single Use Test Devices-. Intended for the in vitro, simultaneous qualitative detection and differentiation of SARS-CoV-2 nucleocapsid antigen and influenza A and/or B. Catalog Number: 256088. Code Information. UDI-DI: N/A Lot Number Expiration Date …Whether Cetaphil products last after the expiration date depends on the product. Some Cetaphil products, like the Gentle Skin Cleanser, have a PAO (Period After Opening) of 12 months, which means it is still good to use for 12 months after opening. However, other Cetaphil products, like the SPF products, have an expiration date of 3 years after ...The Ppd lot number and expiration date are important factors to consider when getting a Tb test. Here's why: Accuracy: Using Ppd from the same lot ensures consistency and accuracy in the test results. Different lots may have variations in potency, which can affect the interpretation of the test. Validity: Using Ppd that is within its expiration ...12-month to 15-month self-life extension granted by the FDA June 16, 2023 Lot number. Tests with this printed expiration date Now have this extended expiration date. 22S0142 - 22S0166The expiration dates listed for these patents are estimates, based on the grant date of the patent. 1) High Certainty: US Patents for TUBERSOL Derived from Brand-Side Litigation No patents found based on brand-side litigation12-month to 15-month self-life extension granted by the FDA June 16, 2023 Lot number. Tests with this printed expiration date Now have this extended expiration date. 22S0142 - 22S0166The NDC Packaged Code 49281-752-22 is assigned to a package of 1 vial, multi-dose in 1 carton / 5 ml in 1 vial, multi-dose (49281-752-98) of Tubersol, a human prescription drug labeled by Sanofi Pasteur Inc.. The product's dosage form is injection, solution and is administered via intradermal form.

Co-Pack Lot Numbers Labelled Co-Pack Expiration Dates Extended Co- Pack Expiration Dates; AZ220126: Aug 2023: Aug 2024: AZ220122: Aug 2023: Aug 2024: AZ220151: Jul 2023: Jul 2024: AZ220155: Jul ...

tb test ppd lot number and expiration date 2022; tb test two step; ppd lot number; tb lot number 2023; filled out tb test form; tubersol lot number and expiration date 2022; what is a 2 step tb test; tb test ppd lot number and expiration date 2023; 2 step tb test process SD Biosensor, Inc.: Pilot COVID-19 At-Home Test 9-month to 12-month shelf-life extension granted by the FDA on October 14, 2022. Lot Number. Tests with this printed expiration date (Year-month-day ...Find the Use By/Expiration Date. Look for this on the top or the bottom of the can. The type is embossed (raised). The Product Identifier is below the Use By/Expiration Date. The Lot Number is below the Product Identifier. Ink Jet batch codes may be under the label or on the bottom of the can.*. The Ink Jet Code may be 4 – 13+ characters long.Aplisol Lot Number And Expiration Date therefore simple!. Our cyber repository hosts in many sites, facilitating you to receive the most less latency time to download any of our books like this one. aplisol lot number and expiration date is accessible in our book gathering an online access to it is set as public so you can get it promptly.A number of factors reported to cause a decreased ability to respond to the tuberculin test, such as the presence of infections, viral infections (measles, mumps, chickenpox, HIV), live virus vaccinations (measles, mumps, rubella, and other live vaccines), bacterial infections (typhoid fever, brucellosis, typhus, leprosy, pertussis ...Some typical uses for the Date Calculators; Date Calculators. Duration Between Two Dates – Calculates number of days; Time and Date Duration – Calculate duration, with both date and time included; Birthday Calculator – Find when you are 1 billion seconds old; Weekday Calculator – What Day is this Date? – Find the weekday for any dateAdminister the test dose (0.1 mL) of TUBERSOL with a 1 mL syringe calibrated in tenths. and fitted with a short, one-quarter to one-half inch, 26 or 27 gauge needle. Wipe the …Tests with this printed Now have this extended Lot Number expiration date. 1. ACON Laboratories, Inc: Flowflex COVID-19 Antigen Home Test 21-month to 24-month self-life extension granted by the FDA on March 15, 2023. Lot Number Tests with this printed expiration date Now have this extended expiration date. COV1100041, COV1100042, COV1100043 ...Learn three important reasons why it's better to put your debit card away and pay with a credit card instead. Editor’s note: This is a recurring post, regularly updated with new in...Nov 14, 2013. #4. Re: Same Lot / Refnumber but different expiration date. You may want to be proactive then and explain the date difference in the documentation (packing slip and/or CoC and/or test data) that ships with any of your products that are generated using this specific pipette tip lot. Whether or not this is a conformance issue may ...

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Typhim Vi® (Typhoid Vi Polysaccharide Vaccine) Vaxelis™ (Diphtheria and Tetanus Toxoids and Acellular Pertussis, Inactivated Poliovirus, Haemophilus b Conjugate and …October 2023 Page 1 : TABLE OF CONTENTS : ... lot numbers and expiry dates may be lost; and post-puncture expiry may elapse or be unknown. Draw ... from date of first puncture, or the vial expiry date if earlier than the post-puncture expiry (1). o In use for an undetermined length of time (i.e. open vials without the date of first puncture)(9).(until expiration date) -58°F to 5°F (-50°C to -15°C) Minimize exposure to room light and avoid exposure to direct sunlight and ultraviolet light. SHIPPED FROZEN Storage After Thawing Option to Store Refrigerated (up to 30 days, until expiration date) 36°F to 46°F (2°C to 8°C) Thawed vials and syringes can be handled in room light ...The first two digits (19) refer to the year of manufacture (2019) The next two digits (03) identify the month the product was manufactured (March) or the date of manufacture. The following two numerals (22) refer to the day of the year. The next figure (4) is the company plant number. The figures (03) represent the product batch of on that day. TUBERSOL Tuberculin Purified Protein Derivative (Mantoux), is indicated to aid diagnosis of tuberculosis infection (TB) in persons at increased risk of developing active disease. Tubersol injection, Sanofi Pasteur, 5 TU/0.1 mL, 1 mL multiple dose vial, NDC 49281-0752-21 ... Estimated Resupply Dates. All presentations are available. Implications for Patient Care. CDC has additional information regarding the anticipated tuberculin shortage as well as management strategies on their website at https: ...April 16th, 2019 - Lot number and expiration date for EpiPen 0 3 mg Auto Injectors and its authorized generic are located on both the carton and auto injector itself Please see example images • On the auto injector the lot number is located at the top of the label in black and preceded by the word ‘LOT.It is the student's responsibility to keep health information up to date and to take action to renew requirements PRIOR to the expiration date on their CastleBranch.com account. Call/Email CastleBranch first if you have trouble. If you still have trouble, then check with Dr. Lupinacci, Dr. Campbell or Terri-Ann Tilquist by email.[11] What is the Listing Expiration Date? - This is the date when the listing record will expire if not updated or certified by the product labeler. [12] What is the NDC Exclude Flag?Aplisol Lot Number And Expiration Date TB Lot Number and Brand PDF documents docs archive net. Aplisol Lot Number And Expiration Date PDF Download. 42023 104 05 NDC ... April 21st, 2018 - Tubersol Aplisol Lot Number Expiration Date Given by TB Certified Staff Signature' 'Page 1 of 6 Tuberculin Purified Protein Derivative … ….

A vial of TUBERSOL which has been entered and in use for 30 days should be discarded. (21) Do not use after expiration date.And Expiration Date Aplisol Lot Number And Expiration Date cetara de. 42023 104 05 NDC Code Aplisol HUMAN PRESCRIPTION DRUG. ... Global TB Center. B Testing Method T Global TB Center. Tubersol FDA prescribing information side effects and uses. Latent Tuberculosis Infection A Guide for Primary Health. APLISOL U S Food and Drug Administration ...April 7, 2023: Find Paxlovid Shelf-Life Expiration Dates in the Searchable COVID-19 Therapeutic Product Database; ... 2023. FDA recognizes that, in rare instances, individuals with a recent known exposure (e.g., a household contact with a positive direct SARS-CoV-2 viral test) who develop signs and symptoms consistent with COVID-19 may be ...by 2015 lot-level, by 2023 package- level) ... - Serial number - Lot Number - Expiration Date • Data Carrier - 2D bar code . Product identification (Serialization) 16 . StandardizedHow do I read a LOT number and determine the expiration date of a particular product? All oral care products and carrier oils will include a printed expiration date after the LOT number.LOT numbers are printed on each and every product we produce at our factory. ... Photo Samples of Lot Numbers: Modified 02.14.2023. Your cart (0 items) Spend ... Tubersol® Tuberculin Purified Protein Derivative 5 TU / 0.1 mL Injection 1 mL. Protect from light:Tuberculin PPD solutions can be adversely affected …. Store at 2 to 8 degrees Celsius (35 to 46 degrees Fahrenheit) Do not freeze. Tubersol® Tuberculin Purified Protein Derivative 5 TU / 0.1 mL Injection 5 mL Sanofi Pasteur 752-22. 21-month to 24-month self-life extension granted by the FDA on March 15, 2023 . Lot Number . ... expiration date Now have this extended expiration date; COV1100041, COV1100042, COV1100043,Before release, each successive lot is tested for potency in comparison with a reference standard. Independent studies conducted by the US Public Health Service in humans have determined the amount of CT68 in stabilized solution necessary (3)(4)(5) to produce bio-equivalency with Tuberculin PPD-S (in phosphate buffer without polysorbate 80) using 5 US units (TU) Tuberculin PPD-S as the standard.Vial Lookup Tool. Expiry dates for 356 Moderna Batches. The CDC List : Pfizer, Moderna and Janssen Lot Expiry Dates. Expiry dates for 439 Biologically Active Lots for Moderna, Pfizer and Janssen (does not include placebo lots) The source for the above "Biologically Active" list is. Source 1. 21-month to 24-month self-life extension granted by the FDA on March 15, 2023 . Lot Number . ... expiration date Now have this extended expiration date; COV1100041, COV1100042, COV1100043, Tubersol lot number and expiration date 2023, 2023410 - This is the correct code. Find the code on the package that looks like this. 520032 69% 36M 8011003804566 20900 - This is not a batch code. Don't enter values that look like this. 6901 - This is the correct code. Find the code on the package that looks like this. 3145891263107 126.310 92200 W1J 6DG - This is not a batch code., TUBERSOL patent expiry, news, international patents, biosimilar launch. TUBERSOL patent expiry, news, international patents, biosimilar launch ... The expiration dates listed for these patents are estimates, based on the grant date of the patent. 1) High Certainty: US Patents for TUBERSOL Derived from Brand-Side Litigation ..., Analyze Korres batch codes. To analyze Korres batch code, and check production date and shelf life for Korres, please enter the batch code in the calculator form. Many companies have periodic batch codes that repeat over time, e.g. repeat each 10 years. Vintage fragrances often do not have batch codes at all., Learn three important reasons why it's better to put your debit card away and pay with a credit card instead. Editor’s note: This is a recurring post, regularly updated with new in..., Abbott Diagnostics Scarborough, Inc.: BinaxNOWTM COVID-19 Ag Self Test 15-month to 22-month shelf-life extension granted by the FDA December 21, 2022. Lot Number., relationship between lot numbers used primarily for inventory and those used for vaccine administration. This table can be used to show patterns of lot numbers as a guide to derive the specific lot number. As more HIM systems adapt to take advantage of 2D barcoded vaccine products on both the unit of sale and unit of use, this table may prove ..., TUBERSOL is a Intradermal Injection, Solution in the Human Prescription Drug category. It is labeled and distributed by Sanofi Pasteur Inc.. The primary component is Tuberculin Purified Protein Derivative. Product ID. 49281-752_57d5fa05-f7af-48d5-90a7-39c0c2121134. NDC. 49281-752. Product Type. Human Prescription Drug., Tubersol® Tuberculin Purified Protein Derivative 5 TU / 0.1 mL Injection 1 mL Sanofi Pasteur 752-21. , The Ppd lot number and expiration date are important factors to consider when getting a Tb test. Here's why: Accuracy: Using Ppd from the same lot ensures consistency and accuracy in the test results. Different lots may have variations in potency, which can affect the interpretation of the test. Validity: Using Ppd that is within its expiration ..., relationship between lot numbers used primarily for inventory and those used for vaccine administration. This table can be used to show patterns of lot numbers as a guide to derive the specific lot number. As more HIM systems adapt to take advantage of 2D barcoded vaccine products on both the unit of sale and unit of use, this table may prove ..., We are pleased to announce that the request to extend the Flowflex COVID-19 Antigen Home Test shelf-life from 12 months to 24 months, when stored at 36-86°F (2-30°C), has been granted. The Flow flex COVID-19 Antigen Home Test has an expiration date that is extended by 12 months. Look up the new expiration date using the lot number printed on ..., Testing has been completed to support a shelf-life (expiration date) of up to 22 months. The BinaxNOW™ COVID-19 Antigen Self Test, part number 195-160 or 195- 180, may now have a longer than labeled product expiry date. All BinaxNOW COVID-19 Antigen Self Test kits currently have a twenty-two-month expiry date. , To find the expiration date for any vial of the Novavax COVID‑19 vaccine, enter the batch/Lot number printed on the carton and vial. ... (2023-2024 Formula) Fact Sheet for Healthcare Providers Administering Vaccine (Vaccination Providers). Welcome to the US Novavax COVID-19 Vaccine, Adjuvanted (2023-2024 Formula) website ..., Tubersol Aplisol Lot Number Expiration Date Given by TB Certified Staff Signature. Aplisol Lot Number And Expiration Date pdf downloads BiologicsBloodVaccines Vaccines ApprovedProducts ucm114924 pdf given dose manufacturer and lot number., The affected lot numbers can be found in Appendix I - Table 1. Shelf-Life Extended Lot Numbers. For more information, please visit our website at . ... expiration date COVSA1001* 2022-11-17 2023-05-17 COVSA1002* 2022-11-19 2023-05-19 COVSA1003* COVSD1001 2022-11-21. 2023-05-21., DESCRIPTION. TUBERSOL ®, Tuberculin Purified Protein Derivative (Mantoux) (PPD) (1) for intradermal tuberculin testing is prepared from a large Master Batch Connaught Tuberculin (CT68) (2) and is a cell-free purified protein fraction obtained from a human strain of Mycobacterium tuberculosis grown on a protein-free synthetic medium and …, Tubersol® NDC #: 49281-0752-22 ... ABC Item Number: 10244365 Code: CPT 86580 Product Type: Refrigerated Shipping Type: Next Day Air ... Indications are updated quarterly and may not reflect the most up to date information. Please consult the Last Updated Date and refer to the manufacturers and FDA information for the latest information., Learn three important reasons why it's better to put your debit card away and pay with a credit card instead. Editor’s note: This is a recurring post, regularly updated with new in..., JJJ - Julian Date of Date Packaged ## Batch number of the day Example 07231991 Manufacture on July 2023, Packed Date 18th, Batch 1. Our previous lot system in the format of letter, number, letter, number such as L2H9 is deciphered as follows: To estimate the expiration date from the lot number, use the 3 rd and 4 th character of the lot number., Click a lot number to open the lot number record. Lot number records identify item name, number, status, memos, and the following: Inventory quantities - For each location the lot number record shows On Hand, On Order, and Available counts. Expiration date - NetSuite can warn you when you sell a lot item that is close to its expiration., Introduced support for expiration dates along with serial and lot numbers for QuickBooks Desktop SDK integrations in QuickBooks Desktop US 2023 version 3. Note: Users won't be able to update expiration dates of existing serial/lot numbers via the SDK.It 'll only be possible from the Desktop app UI along with the consent to change the ..., Find the Use By/Expiration Date. Look for this on the top or the bottom of the can. The type is embossed (raised). The Product Identifier is below the Use By/Expiration Date. The Lot Number is below the Product Identifier. Ink Jet batch codes may be under the label or on the bottom of the can.*. The Ink Jet Code may be 4 - 13+ characters long., April 16th, 2019 - Lot number and expiration date for EpiPen 0 3 mg Auto Injectors and its authorized generic are located on both the carton and auto injector itself Please see example images • On the auto injector the lot number is located at the top of the label in black and preceded by the word ‘LOT., step ppd office of clinical placement tubersol lot number and expiration date 2023 what you need nyc tubersol lot number and expiration date 2022 what you dates of ..., Vial Expiration Checker. To find the expiration for any Moderna COVID-19 Vaccine, locate the lot number printed on the carton and vial. Enter the lot number exactly as shown in the field below and press "Submit." Please note, this tool is not validated to authenticate or confirm legitimacy of vaccine. For any further questions contact Moderna., TUBERSOL is a Intradermal Injection, Solution in the Human Prescription Drug category. It is labeled and distributed by Sanofi Pasteur Inc.. The primary component is Tuberculin Purified Protein Derivative. Product ID. 49281-752_57d5fa05-f7af-48d5-90a7-39c0c2121134. NDC. 49281-752. Product Type. Human Prescription Drug., Oct. 14, 2023 9:00 a.m. PT. ... The links below include lot numbers and expiration dates for the brands of at-home COVID-19 tests that have had their expiration dates extended by the FDA. You can ..., 19221 is 2019. The last three numbers represent the day (out of 365) that the food was manufactured. Remember, day #1 is January 1; day #365 is December 31 st. So, for the examples above, the 114 th day of 2021 was April 24 th, meaning April 24, 2021 is the manufactured date for the food item. Here are the dates for the other examples:, Carestart Expiration Extension Revised December 2021. The FDA has granted an expiration date extension for several lot numbers of the Carestart Covid-19 Antigen tests. For more information, and to get your new expiration date click the below link. CareStart COVID-19 Ag Exp Date Extension Notice_V6 (16 Months), Abbott recently received an extension from the U.S. FDA for BinaxNOW Self Tests from 15-month expiration dates to 22-months. Here's how you can confirm what your new expiration may be: Look on the back of your box for both the expiration date (next to the hourglass symbol) and lot number (next to the words LOT)., Vaccine Information Statements. Vaccine Information Statements are information sheets produced by CDC that explain both the benefits and risks of a vaccine to vaccine recipients. In the case of recipients under 18, they are provided to a parent or legal guardian. Federal law requires that VISs be handed out before each dose of certain vaccinations., For example, inactivated polio vaccine in an MDV can be used through the expiration date on the vial. For some vaccines, the manufacturer specifies that once the MDV has been entered or the rubber stopper punctured, the vaccine must be used within a certain number of days. This is commonly referred to as the "beyond-use date" (BUD)., Document the test: • Record the date and time of test, tuberculin lot number, expiration date, dose of PPD, the site of • Store Tubersol® in the refrigerator between 2°C and injection and the person administering the TST. [...] If result of the first TST is positive, a second TST increased risk for the development of tuberculosis and ...