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Sildenafil citrate is a white to off-white powder, slightly soluble in water and methanol with a molecular weight of 666.7. Sildenafil tablets, USP are formulated as blue, film-coated oval biconvex tablets equivalent to 25 mg, 50 mg and 100 mg of sildenafil for oral administration.

1. Introduction. Sildenafil, the first drug developed for the treatment of erectile dysfunction, is a highly selective inhibitor of phosphodiesterase (PDE) type 5 [].By inhibiting phosphodiesterase, it increases the intracellular concentrations of cyclic guanosine monophosphate (cGMP), causing an amplification of the endogenous nitric oxide (NO)-cGMP signaling (eNOS) pathway, thus enhancing ...The effects may be increased because of slower removal of the medicine from the body. Leukemia (blood related cancer) or. Multiple myeloma (blood related cancer) or. Sickle-cell anemia (blood disorder)—Sildenafil should be used with caution in these patients as problems with prolonged erection of the penis may occur.Nivagen's 5% Lidocaine cream was formulated to quickly numb pain, itching, and burning caused by hemorrhoids and other anorectal disorders. Simply apply the Lidocaine ointment to the affected area to get instant relief. Use the finger cots for quick and easy application. Apply At First Sign Of DiscomfortNiva Thyroid (thyroid tablets, USP)* for oral use is a natural preparation derived from porcine thyroid glands and has a strong, characteristic odor. (T3 liothyronine is approximately four times as potent as T4 levothyroxine on a microgram for microgram basis.) They provide 38 mcg levothyroxine (T4) and 9 mcg liothyronine (T3) per grain of thyroid.Up to 50% of men experience erectile dysfunction (ED) by age 50. And this percentage increases with age. For many men with ED, sildenafil (Viagra) is a first-choice medication to help get or maintain an erection. But high blood pressure, heart disease, and prostate problems are also more common in men as they get older.And many of the medications that are taken for these conditions interact ...Sildenafil citrate (often shortened to “sildenafil”) is the main ingredient in Viagra. After parent company Pfizer’s patent expired, other manufacturers were allowed to manufacture generic Viagra under the name of its generic ingredient, sildenafil. The terms are pretty much interchangeable, the way you might say “Kleenex®” to refer ...Cheap Flight Day is supposedly August 23, when airfare is cheaper. But the truth about finding cheap flights, and when to book for the best prices, is complicated. By clicking "TRY...

5.1 Hypotension. Sildenafil has vasodilatory properties, resulting in mild and transient decreases in blood pressure. Before prescribing sildenafil, carefully consider whether patients with certain underlying conditions could be adversely affected by such vasodilatory effects (e.g., patients on antihypertensive therapy or with resting hypotension [blood pressure less than 90/50], fluid ...DESCRIPTION. VIAGRA®, an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Sildenafil citrate is a white to off-white crystalline powder with a solubility of 3.5 mg/mL in water and a molecular weight of 666.7.The drugs are phosphodiesterase 5 (PDE5) inhibitors, and their brand and generic names, respectively, are Viagra (sildenafil), Cialis (tadalafil), Levitra (vardenafil), and Stendra (avanafil ...Sildenafil tablets are indicated for the treatment of erectile dysfunction. 2.1 Dosage Information - For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, sildenafil tablets may be taken anywhere from 30 ... Sildenafil tablets USP are supplied as white to off-white, film …Dec 27, 2023 · Physicians should advise patients to stop taking PDE5 inhibitors, including sildenafil , and seek prompt medical attention in the event of sudden decrease or loss of hearing. These events, which may be accompanied by tinnitus and dizziness, have been reported in temporal association to the intake of PDE5 inhibitors, including sildenafil .

sildenafil citrate 100 mg. OVAL BLUE 1A1. View Drug. NIVAGEN PHARMACEUTICALS, INC. sildenafil citrate 100 mg. OVAL BLUE 1A1. View Drug. NIVAGEN PHARMACEUTICALS, INC. sildenafil citrate 100 mg. OVAL BLUE 1A1. View Drug. x Try the Professional Version. Faster Pill Identifier; Voice Search;A typical starting dose of sildenafil is 50 milligrams, which you'd take 30 minutes to four hours before sexy time. Your provider may adjust your dosage depending on your needs and how you respond to the medication. It's also possible to be prescribed doses in multiples of 20 mg, including 20 mg, 40 mg, 60 mg and 80 mg.Abstract. Sildenafil is a phosphodiesterase type 5 inhibitor that is approved to treat erectile dysfunction and pulmonary hypertension. Generally, sildenafil is safe, with mild side effects. Here, we report a case of acute kidney injury caused by a sildenafil overdose. A 67-year-old man took 400 mg of sildenafil for erectile dysfunction.The average length of time Viagra lasts. On average, Viagra lasts between 2 and 3 hours before its effects start to diminish. Viagra can last up to 5 hours or longer depending on your dosage, your ...Search Drug Prescription, OTC, and Pets. Search by Drug Name, Pill Imprint, NDC codes. Pill ID by Shape, Color, Size, and Score. Database Powered by the National Library of Medicine. AIDS and CANCER drugs. Compare Drug Prices with Coupons. Up-to-Date DailyMed Drug Information with PDFs.Sildenafil Revatio. Strengths & Sizes. 20mg/ 90 count. Note: product and packaging images are not actual size. NDC# 31722-776-90; UPC Code 331722776905; Imprint J/95; GPI Code 40143060100320; Download Label. Download HDA Sheet. Product Info. Dosage Form Tablet; TE Code AB; Brand Reference Revatio;

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2.1 Important Administration Instructions - Calcium Gluconate Injection contains 100 mg of calcium gluconate per mL which contains 9.3 mg (i.e., 0.465 mEq) of elemental calcium. Dilute ... Calcium Gluconate Injection, USP is a clear, colorless to slightly yellow, solution free from visible particles available in the following: Single dose vial ...Order sildenafil 50mg for sale. However, little glucose is deposited in the brain. The energy needs of the cells of the central nervous system are very high. Brain tissue consumes 30 times more oxygen than muscle tissue. Glucose deficiency is accompanied by a decrease in oxygen consumption by the cells of the central nervous system, even with ...Sildenafil (Revatio) is a phosphodiesterase 5 (PDE-5) blocker that relaxes blood vessels in the lungs. This allows blood to flow better and lowers the blood pressure in the lungs. Your heart is able to pump better, your body gets more oxygen, and you should be able to breathe and exercise more easily. PDE-5 blockers also relax blood vessels in ...Vardenafil side effects. About 40 percent of people experience side effects that are usually mild when taking PDE5 inhibitors. The most common side effects of vardenafil include: dizziness ...

Sildenafil caused a significant reduction of the postejaculatory refractory time (12/30 vs 4/30) (chi(2) test, P=0.04). Sildenafil does not improve erections in young healthy men. Sildenafil should not be given to young healthy men to improve their erections and patients should be advised against recreational abuse of the drug.Sildenafil is a phosphodiesterase-5 (PDE5) inhibitor... SILDENAFIL CITRATE (Page 2 of 7) REMEDYREPACK INC. 27 December 2023. 5.4 Hearing Loss. Physicians should advise patients to stop taking PDE5 inhibitors, including sildenafil , and seek prompt medical attention in the event of sudden decrease or loss of hearing. These … Key facts. Sildenafil (Viagra) is a medicine used to treat erectile dysfunction (ED, also called impotence). Sildenafil works by helping to relax the blood vessels in the penis, allowing more blood to flow in and cause an erection. You should take sildenafil about an hour before planned sexual activity, so it has time to work. Nivagen Pharmaceuticals is a company specializing in the development, acquisition, and sales of generic prescription drugs. It launches and markets complex generic products across a range of dosage forms and technology platforms. Type Private Status Active Founded 2009 HQPatients randomly received 12 weeks of treatment with sildenafil citrate 50 mg or placebo. A significant improvement of arousal sensation, lubrication, and orgasm was reported in the study group affected by primary FSAD. On the contrary, women affected by different types of FSDs (eg, hypoactive sexual disorder, dyspareunia due to vaginal ...sildenafil citrate tablet, film coated NDC Code(s): 50436-0035-1, 50436-0036-1Sildenafil inhibits the enzyme phosphodiesterase type 5 (PDE5); PDE5 inactivates cGMP. Revatio: Produces vasodilation of the pulmonary vascular bed. Therapeutic Effects: Viagra: Enhanced blood flow to the corpus cavernosum and erection sufficient to allow sexual intercourse. Requires sexual stimulation.Key takeaways: Viagra (sildenafil) is a prescription medication that treats erectile dysfunction (ED). Viagra is an oral medication. It’s available as 25 mg, 50 mg, and 100 mg tablets. You can take a dose about 1 hour before sexual activity. Viagra is available as a lower-cost generic.

Sildenafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. It works if you have erection problems by temporarily increasing blood flow to your penis when you get sexually excited.. It works in pulmonary hypertension by relaxing blood vessels in your chest. This increases the blood supply to your lungs and reduces the workload of your heart.

We developed an endophenotype disease module-based methodology for Alzheimer’s disease (AD) drug repurposing and identified sildenafil as a potential disease risk modifier. Based on ...Pros. There are no pros for working here. Cons. -Toxic work environment and terrible communication from management -Management is very rude and condescending -Grunt work with no opportunities to move up, I felt like a janitor cleaning up everyone's messes -Very messy and unorganized lab spaces. Show More.Nivagen Pharmaceuticals's annual revenue is $2.0M. Zippia's data science team found the following key financial metrics about Nivagen Pharmaceuticals after extensive research and analysis. Nivagen Pharmaceuticals has 35 employees, and the revenue per employee ratio is $58,000. Nivagen Pharmaceuticals peak revenue was $2.0M in 2023.Most men aged 18 and over can take sildenafil for erectile dysfunction. Most adults and children aged 1 year and over can take sildenafil for pulmonary hypertension. Who may not be able to take sildenafil. Sildenafil is not suitable for some people. To make sure it's safe for you, speak to your doctor or pharmacist before taking sildenafil if you:Abstract. Background: A growing number of prescription medicines such as Viagra are offered and sold directly to consumers on the Internet. Little is known about the structure and "quality" of these "virtual pharmacies" in terms of how responsibly "online-prescriptions" are actually issued. Objective: To determine to what extent Viagra is sold ...When their patents finally expired in April 2020, [3][4] other companies started offering Generic Viagra® and Generic Cialis® for less—typically $10-33 per 100 mg tablet of Generic Viagra and $10-$53 per 20 mg tablet of Generic Cialis. We founded Friday Plans…Sildenafil tablets are indicated for the treatment of erectile dysfunction. Sildenafil is a phosphodiesterase-5 (PDE5)... SILDENAFIL CITRATE (Page 7 of 9) NIVAGEN PHARMACEUTICALS, INC. 8 December 2022. 13 NONCLINICAL TOXICOLOGY 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility.Oral PDE-5 inhibitors such as sildenafil, vardenafil, tadalafil, and avanafil have provided noninvasive, effective, well-tolerated treatment for erectile dysfunction (ED) patients and, at the same time, stimulated both academic and clinical interests. Lately, some oral PDE-5 inhibitors were released as low-dose preparations with the concept of ...Sildenafil tablets contain the same active ingredient as Viagra (sildenafil citrate). Sildenafil is a generic, common ED treatment and is as effective as branded Viagra. Effective for 62-82% of men. Works in 1 hour and lasts …

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Aildenafil (methisosildenafil) is a synthetic drug that is a structural analog of sildenafil (Viagra). It was first reported in 2003. Like sildenafil, aildenafil is a phosphodiesterase type 5 inhibitor.. Aildenafil has been found as an adulterant in a variety of supplements which are sold as "natural" or "herbal" sexual enhancement products. The United States Food and Drug Administration has ...Sildenafil is a medication used in the management and treatment of erectile dysfunction and pulmonary arterial hypertension. It is in the phosphodiesterase-5 inhibitor (PDE5-I) class of medications. This activity describes the indications, actions, adverse effects, and contraindications of sildenafil as an agent in the clinical setting.Tadalafil (Cialis) Cialis is an oral tablet that starts to work about 30 minutes after you take it. It can improve erectile function for up to 36 hours. The starting daily dose range is 2.5 to 5 ...Serious side effects. This list contains examples of serious side effects that can occur with Cialis and Viagra when taken individually. prolonged erection (an erection that lasts more than 4 ...Sildenafil (Viagra ®; Pfizer, New York, USA) was Pfizer's blockbuster wonder drug as "blue pill" for erectile dysfunction (ED) which sold like hot cakes soon after its release.Although it ...Tax. $455.44. Total. $ 6,148.44. Buy cheap Viagra 100mg online. Free prescription. Fast delivery. It's a perfect, easy solution for men that suffer from erectile dysfunction.Sildenafil Tablets - White to off white colored, round shaped, biconvex, film coated tablets debossed with 'J' on one side and '95' on the other side. 4 CONTRAINDICATIONS. Sildenafil is contraindicated in patients with: Concomitant use of organic nitrates in any form, either regularly or intermittently, because of the greater risk of ...The most common natural Viagra alternatives you'll see online and in research are: arginine, ginseng, yohimbe, ginkgo biloba, and epimedium (horny goat weed). These traditional and herbal E.D. remedies do contain substances that may have an effect on E.D. symptoms and underling causes, but they're generally not powerful enough to have a ... ….

Sildenafil is used to treat men who have erectile dysfunction (also called sexual impotence). Sildenafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. The penis is one of the areas where this enzyme works.You have been prescribed Sildenafil + Dapoxetine for the treatment of premature ejaculation with erectile dysfunction. Take it 1 to 3 hours before anticipated sexual activity. Do not take it more than once every 24 hours or every day. Do not drive or do anything requiring concentration until you know how Sildenafil + Dapoxetine affects you.Nivagen Pharmaceuticals, Inc. and Hikma Pharmaceuticals USA Inc. Case Number: 1:2023cv00137: Filed: February 6, 2023: Court: US District Court for the District of Delaware: Presiding Judge: Maryellen Noreika: Nature of Suit: Patent - Abbreviated New Drug Application(ANDA) Cause of Action: 35 U.S.C. § 271 Patent Infringement: Jury Demanded By ...Sildenafil (Viagra) is a phosphodiesterase-5 (PDE-5) inhibitor. PDE-5 is a protein in your body that breaks down the molecules that normally cause an erection. When it blocks PDE-5, sildenafil (Viagra) helps an erection occur by allowing certain muscles in the penis to relax and the penis to fill with blood. info.Both Sildenafil and Tadalafil are PED5 inhibitors that increase blood flow to the penis. They both can take effect in as little as in 30 minutes help men achieve stronger and firmer erections. They also have similar potential side effects. Sildenafil is the active ingredient found in Viagra, the first drug ever approved to treat ED symptoms.Udenafil is a potent novel phosphodiesterase-5 inhibitor approved for use in Korea. Udenafil has unique properties, with a T max of 1.0-1.5 h and a T 1/2 of 11-13 h (a relatively rapid onset and a long duration of action). Therefore, both on-demand and once-daily use of udenafil have been reported. Udenafil's efficacy and tolerability ...Sildenafil is a medicine used to treat erection problems ( erectile dysfunction ). Sildenafil is also sometimes used to treat pulmonary hypertension (high blood pressure in the blood vessels that supply the lungs). If you have erection problems sildenafil works by temporarily increasing blood flow to your penis when you get sexually excited.Although rare, sildenafil can also cause more serious side effects, including some that may need immediate medical attention. Severe side effects include: In very rare cases, sildenafil may also cause priapism — a prolonged and painful erection that may last for four hours or longer. Nivagen sildenafil, If you're interested in oral ED medication, these are your 4 options. Viagra ( sildenafil) Cialis and Cialis Daily ( tadalafil) Levitra, Staxyn (vardenafil) Stendra (avanafil) Each of the generics contains the same active ingredients in the same concentrations as the higher-cost, branded medications., Manufactured for: Nivagen Pharmaceuticals, Inc. Sacramento, CA 95827, USA Toll free number: 1-877-977-0687 Revision Date: 04/2023; V-02 Patient Information Tadalafil (ta·dal·a·fil) Tablets Read this important information before you start taking tadalafil tablets and each time you get a refill., Learn about uses, how it works, and more for Viagra (sildenafil). It's a prescription drug that treats erectile dysfunction (ED) in adult males., VIAGRA®, an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Sildenafil citrate is a white to off-white crystalline powder with a solubility of 3.5 mg/mL in water and a molecular weight of 666.7., Viagra (sildenafil) became the first FDA-approved medication of its kind in 1998. It’s used to treat erectile dysfunction (ED), which is when you have difficulty achieving or maintaining an erection for sex. Now, it’s one of several other ED medications in the same class.. Viagra is a phosphodiesterase 5 (PDE5) inhibitor.It works by causing more blood …, Sildenafil Tablets - White to off white colored, round shaped, biconvex, film coated tablets debossed with 'J' on one side and '95' on the other side. 4 CONTRAINDICATIONS. Sildenafil is contraindicated in patients with: Concomitant use of organic nitrates in any form, either regularly or intermittently, because of the greater risk of ..., Dosage. The dose of Cialis you need will depend on whether you're taking it daily or as needed. Daily doses are often between 2.5 and 5 mg. The as-needed dose is usually 10 mg but can range from 5-20 mg. The typical dose of Viagra is 50 mg. However, the dosage can range from 25-100 mg., sildenafil citrate 100 mg. OVAL BLUE 1A1. View Drug. NIVAGEN PHARMACEUTICALS, INC. sildenafil citrate 100 mg. OVAL BLUE 1A1. View Drug. NIVAGEN PHARMACEUTICALS, INC. sildenafil citrate 100 mg. OVAL BLUE 1A1. View Drug. x Try the Professional Version. Faster Pill Identifier; Voice Search;, Yes, Sildenafil Citrate with product code 75834-241 is active and included in the NDC Directory. The product was first marketed by Nivagen Pharmaceuticals, Inc. on September 04, 2020 and its listing in the NDC Directory is set to expire on December 31, 2024 if the product is not updated or renewed by the manufacturer., Tadalafil (Cialis) is taken by mouth either as needed before sexual activity or once daily for erectile dysfunction (ED).It's also taken once daily to treat symptoms from an enlarged prostate (benign prostatic hyperplasia, or BPH).Tadalafil (Cialis) is available both as brand-name and generic tablets. Common side effects of this medication include headache and indigestion., VIAGRA®, an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Sildenafil citrate is a white to off-white crystalline powder with a solubility of 3.5 mg/mL in water and a molecular weight of 666.7., Maria Hudson. 4 hrs. ago. Anna Nelson. 6 hrs. ago. David Muldon. 8 hrs. ago, Sildenafil tablets (Revatio®) for the treatment of pulmonary arterial hypertension (February 2010) Funding decision: Recommended with restrictions. SMC No. 688/11. Sildenafil injection (Revatio®) for the treatment of pulmonary arterial hypertension (PAH) in patients who are unable to take sildenafil orally (March 2011), Sildenafil | C22H30N6O4S | CID 135398744 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ..., Sildenafil has an average rating of 8.2 out of 10 from a total of 506 ratings on Drugs.com. 78% of reviewers reported a positive effect, while 12% reported a negative effect. Vardenafil has an average rating of 8.0 out of 10 from a total of 173 ratings on Drugs.com. 75% of reviewers reported a positive effect, while 10% reported a negative ..., Email provides a fast, low-cost, efficient way to keep your employees and business partners informed and up to date. Email contact lists, however, sometimes contain street addresse..., Sildenafil (Viagra) is the most effective oral therapy currently available for erectile dysfunction. Patients should be given clear instructions regarding the use of sildenafil. The most common side effects include flushing, headaches, dyspepsia, and transient visual changes. In combination with nitrates, it can and has caused fatal hypotension., Flibanserin (Addyi) is a Viagra-like drug for cisgender women and others assigned female at birth. Currently, Addyi is only available through certain prescribers and pharmacies. Addyi was approved ..., Results. A total of 220 patients were randomized to receive either avanafil tablets 100 mg or sildenafil tablets 50 mg in 1:1 ratio. After 4 weeks of treatment, 40.0% of patients in the avanafil group and 45.6% of patients in the sildenafil group required dose escalation to a high dose (avanafil 200 mg/sildenafil 100 mg)., Sildenafil has an average rating of 8.2 out of 10 from a total of 506 ratings on Drugs.com. 78% of reviewers reported a positive effect, while 12% reported a negative effect. Vardenafil has an average rating of 8.0 out of 10 from a total of 173 ratings on Drugs.com. 75% of reviewers reported a positive effect, while 10% reported a negative ..., Niva Thyroid (thyroid tablets, USP)* for oral use is a natural preparation derived from porcine thyroid glands and has a strong, characteristic odor. (T3 liothyronine is approximately four times as potent as T4 levothyroxine on a microgram for microgram basis.) They provide 38 mcg levothyroxine (T4) and 9 mcg liothyronine (T3) per grain of thyroid., Sildenafil citrate, USP is a white to off-white crystalline powder with a solubility of 3.5 mg/mL in water and a molecular weight of 666.7. Sildenafil Tablets USP: Sildenafil citrate is formulated as white, film-coated round tablets for oral administration. Each tablet contains sildenafil citrate equivalent to 20 mg of sildenafil., Sildenafil Teva is a medicine that contains the active substance sildenafil. It is available as tablets (25, 50 and 100 mg). Sildenafil Teva is a ‘generic medicine’. This means that Sildenafil Teva is similar to a ‘reference medicine’ already authorised in the European Union (EU) called Viagra., SILDENAFIL FOR ORAL SUSPENSION (sildenafil citrate) powder, for suspension. NDC Code (s): 72205-035-76. Packager: Novadoz Pharmaceuticals LLC., Abstract. Background: A growing number of prescription medicines such as Viagra are offered and sold directly to consumers on the Internet. Little is known about the structure and "quality" of these "virtual pharmacies" in terms of how responsibly "online-prescriptions" are actually issued. Objective: To determine to what extent Viagra is sold ..., Schimke immuno-osseous dysplasia is a condition characterized by short stature, kidney disease, and a weakened immune system. Explore symptoms, inheritance, genetics of this condit..., Sildenafil (Viagra) is a phosphodiesterase-5 (PDE-5) inhibitor. PDE-5 is a protein in your body that breaks down the molecules that normally cause an erection. When it blocks PDE-5, sildenafil (Viagra) helps an erection occur by allowing certain muscles in the penis to relax and the penis to fill with blood. info., Viagra (sildenafil citrate)Company: PfizerApplication No.: 020895Approval Date: 3/27/1998. Persons with disabilities having problems accessing the PDF files below may call (301) 796-3634 for assistance. FDA's Clinical, Statistical and Biopharmacological Review of Viagra Clinical Development. Cover Sheet (PDF) (3/27/1998), Abstract. To investigate the effects of two different dosages of sildenafil on patients with erectile dysfunction (ED), a total of 3,674 patients with ED were recruited to answer questionnaires designed specifically for this study. There were 977 patients in the 50 mg group and there were 2,697 patients in the 100 mg group., Sildenafil tablets are indicated for the treatment of erectile dysfunction. 2 DOSAGE AND ADMINISTRATION. 2.1 Dosage Information - For most patients, the …, sildenafil citrate 100 mg. 1 INDICATIONS AND USAGE Sildenafil tablets are indicated for the treatment of erectile dysfunction. Sildenafil is a phosphodiesterase-5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction (ED) NIVAGEN PHARMACEUTICALS, INC. Identify Pill. , Sildenafil tablets are indicated for the treatment of erectile dysfunction. 2.1 Dosage Information - For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. However, Sildenafil tablets may be taken anywhere from ... Sildenafil tablets USP are supplied as blue, round, biconvex, film-coated ..., 1. Introduction. Sildenafil, the first drug developed for the treatment of erectile dysfunction, is a highly selective inhibitor of phosphodiesterase (PDE) type 5 [].By inhibiting phosphodiesterase, it increases the intracellular concentrations of cyclic guanosine monophosphate (cGMP), causing an amplification of the endogenous nitric oxide (NO)-cGMP signaling (eNOS) pathway, thus enhancing ...